Coumarin CAS NO.588676-07-7

FORMULA C9H602 MOL WT. 146.15 H.S. CODE 2932.21 TOXICITY Oral rat LD50:293 mg/kg SYNONYMS 1,2-Benzopyrone; 2-Oxo- 1,2-benzopyran; PHYSICAL STATE …

FORMULA C9H602 MOL WT. 146.15 H.S. CODE 2932.21 TOXICITY Oral rat LD50:293 mg/kg SYNONYMS 1,2-Benzopyrone; 2-Oxo- 1,2-benzopyran; PHYSICAL STATE white crystalline solid MELTING POINT 69 - 73 BOILING POINT 298 SPECIFIC GRAVITY 0.935 SOLUBILITY IN WATER Slightly soluble VAPOR DENSITY 5.04 NFPA RATINGS Health: 2; Flammability: 0; Reactivity: 0 FLASH POINT 150 STABILITY Stable under ordinary conditions GENERAL DESCRIPTION & APPLICATIONS Coumarin (anhydride of o-coumaric acid) is white, crystalline lactone, obtainable naturally from several plants, such as tonka bean, lavender, sweet clover grass, strawberries, and cinnamon, or produced synthetically from an amino acid, phenylalanine. It is the principle of dicumarol which inhibits the hepatic synthesis of the vitamin K-dependent coagulation factors. Coumarin derivatives are used widely as anticoagulants (such as warfarin, -OH group is attached at 4 position) for the treatment of disorders in which there is excessive or undesirable clotting, such as thrombophlebitis, pulmonary embolism, and certain cardiac conditions. Coumarin derivatives are also used as rodenticides due to the property of causing fatal hemorrhaging. Coumarin has the characteristic odour like that of vanilla beans. It is used for the preparation of perfumes, soaps, flavourings. The coumarin nucleus (benzo-2-pyrone) is derived cinnamic acid (phenylacrylic skeleton) in the biosynthesis. Accordingly, the hydroxy group attached to coumarin structure at 7 position is important in biosynthesis pathway. Umbelliferone (7-hydroxy coumarin), esculetin (6,7-Dihydroxycoumarin), scopoletin (7-hydroxy-6-methoxycoumarin) are the widespread coumarins in nature. Synthetic 7-hydroxy coumarins are used to absorb ultraviolet rays in sunscreen cosmetics and used in the synthesis of drugs especially anticancer.